Second-generation antimalarial endoperoxides

被引：91

作者：

Meshnick, SR

Jefford, CW

Posner, GH

Avery, MA

Peters, W

机构：

[1] UNIV GENEVA,DEPT ORGAN CHEM,CH-1211 GENEVA,SWITZERLAND

[2] JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218

[3] UNIV MISSISSIPPI,DEPT MED CHEM,UNIVERSITY,MS 38677

[4] UNIV MICHIGAN,SCH PUBL HLTH,DEPT EPIDEMIOL,ANN ARBOR,MI 48109

[5] CAB INT,INST PATHOL,ST ALBANS AL4 0XU,ENGLAND

来源：

PARASITOLOGY TODAY | 1996年 / 12卷 / 02期

关键词：

D O I：

10.1016/0169-4758(96)80660-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Artemisinin, derived from a Chinese herbal remedy, is a potent peroxide-containing antimalarial. New types of peroxides, derived from this structure, as well as other naturally occurring antimalarial peroxides, have been synthesized and found to have potent antimalarial activities. Studies on the activities, modes of action, and toxicities of these compounds are discussed here by Steven Meshnick and colleagues.

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页码：79 / 82

页数：4

相关论文

共 14 条

[1] REACTION OF ANTIMALARIAL ENDOPEROXIDES WITH SPECIFIC PARASITE PROTEINS [J].

ASAWAMAHASAKDA, W ;

ITTARAT, I ;

PU, YM ;

ZIFFER, H ;

MESHNICK, SR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (08) :1854-1858

[2] STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE ANTIMALARIAL AGENT ARTEMISININ .1. SYNTHESIS AND COMPARATIVE MOLECULAR-FIELD ANALYSIS OF C-9 ANALOGS OF ARTEMISININ AND 10-DEOXOARTEMISININ [J].

AVERY, MA ;

GAO, FG ;

CHONG, WKM ;

MEHROTRA, S ;

MILHOUS, WK .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (26) :4264-4275

[3]

BRADLEY DJ, 1994, TROP MED PARASITOL, V45, P259

[4] FATAL NEUROTOXICITY OF ARTEETHER AND ARTEMETHER [J].

BREWER, TG ;

GRATE, SJ ;

PEGGINS, JO ;

WEINA, PJ ;

PETRAS, JM ;

LEVINE, BS ;

HEIFFER, MH ;

SCHUSTER, BG .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 51 (03) :251-259

[5]

HIEN TT, 1993, LANCET, V341, P603

[6] SYNTHESIS, STRUCTURE, AND ANTIMALARIAL ACTIVITY OF TRICYCLIC 1,2,4-TRIOXANES RELATED TO ARTEMISININ [J].

JEFFORD, CW ;

VELARDE, JA ;

BERNARDINELLI, G ;

BRAY, DH ;

WARHURST, DC ;

MILHOUS, WK .

HELVETICA CHIMICA ACTA, 1993, 76 (08) :2775-2788

[7] THE DECOMPOSITION OF CIS-FUSED CYCLOPENTENO-1,2,4-TRIOXANES INDUCED BY FERROUS SALTS AND SOME OXOPHILIC REAGENTS [J].

JEFFORD, CW ;

FAVARGER, F ;

VICENTE, MDGH ;

JACQUIER, Y .

HELVETICA CHIMICA ACTA, 1995, 78 (02) :452-458

[8] SYNTHESIS, STRUCTURE, AND ANTIMALARIAL ACTIVITY OF SOME ENANTIOMERICALLY PURE, CIS-FUSED CYCLOPENTENO-1,2,4-TRIOXANES [J].

JEFFORD, CW ;

KOHMOTO, S ;

JAGGI, D ;

TIMARI, G ;

ROSSIER, JC ;

RUDAZ, M ;

BARBUZZI, O ;

GERARD, D ;

BURGER, U ;

KAMALAPRIJA, P ;

MAREDA, J ;

BERNARDINELLI, G ;

MANZANARES, I ;

CANFIELD, CJ ;

FLECK, SL ;

ROBINSON, BL ;

PETERS, W .

HELVETICA CHIMICA ACTA, 1995, 78 (03) :647-662

[9] IRON-DEPENDENT FREE-RADICAL GENERATION FROM THE ANTIMALARIAL AGENT ARTEMISININ (QINGHAOSU) [J].

MESHNICK, SR ;

YANG, YZ ;

LIMA, V ;

KUYPERS, F ;

KAMCHONWONGPAISAN, S ;

YUTHAVONG, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (05) :1108-1114

[10] STRUCTURE-ACTIVITY-RELATIONSHIPS OF LACTONE RING-OPENED ANALOGS OF THE ANTIMALARIAL 1,2,4-TRIOXANE ARTEMISININ [J].

POSNER, GH ;

MCGARVEY, DJ ;

OH, CH ;

KUMAR, N ;

MESHNICK, SR ;

ASAWAMAHASADKA, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (04) :607-612