The role of transforming growth factor β1 in the vascular system

被引：58

作者：

Ghosh, J

Murphy, MO

Turner, N

Khwaja, N

Halka, A

Kielty, CM

Walker, MG

机构：

[1] Manchester Royal Infirm, Dept Vasc Surg, Manchester M13 9WL, Lancs, England

[2] Univ Manchester, UK Ctr Tissue Engn, Manchester, Lancs, England

来源：

CARDIOVASCULAR PATHOLOGY | 2005年 / 14卷 / 01期

关键词：

transforming growth factor; vasculature; angiogenesis; restenosis; hypertension;

D O I：

10.1016/j.carpath.2004.11.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The transforming growth factor beta(TGFbeta) family of cytokines exert pleiotropic effects upon a wide variety of cell types. TGFbeta(1) has been demonstrated to be of fundamental importance in the development, physiology and pathology of the vascular system. As the role of TGFbeta(1) in these processes becomes clearer, influencing its activity for therapeutic benefit is now beginning to be investigated. This review presents an overview of the role of TGFbeta(1) in the vasculature. The cellular and extracellular biology of the TGFbeta family is first addressed, followed by an overview of the function of TGFbeta(1), during vascular development, atherogenesis, hypertension, and vessel injury. (C) 2005 Elsevier Inc. All rights reserved.

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收藏

页码：28 / 36

页数：9

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