Excitation and sensitization of the heat response induced by a phorbol ester in canine visceral polymodal receptors studied in vitro

被引：24

作者：

Leng, SH ^{[1
]}

Mizumura, K ^{[1
]}

Koda, H ^{[1
]}

Kumazawa, T ^{[1
]}

机构：

[1] NAGOYA UNIV,DEPT NEURAL REGULAT,ENVIRONM MED RES INST,NAGOYA,AICHI 46401,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 206卷 / 01期

关键词：

phorbol ester; excitation; sensitization; heat response; polymodal receptor; nociceptor;

D O I：

10.1016/0304-3940(96)12414-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7) 10(-6), and 10(-5) M) for 5 min evoked a significant increase in the ongoing activity of the PMRs within 15 min. PDBu (10(-8) to 10(-5) M) significantly augmented the subsequent heat responses of the PMRs. Staurosporine (10(-6) M), a PK inhibitor, attenuated the effect of PDBu on heat responses. These data suggest that activation of PKC contributes to the activities of PMRs.

引用

页码：13 / 16

页数：4

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