c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

被引：635

作者：

Woodward, Joshua J. ^{[1
]}

Iavarone, Anthony T. ^{[2
]}

Portnoy, Daniel A. ^{[1
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cellular Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Chem Mass Spectrometry Facil QB3, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

来源：

SCIENCE | 2010年 / 328卷 / 5986期

关键词：

CHECKPOINT PROTEIN; ESSENTIAL GENES; RECOGNITION; FLAGELLIN; TRANSPORTERS; INFECTION; BACTERIA; REQUIRES;

D O I：

10.1126/science.1189801

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intracellular bacterial pathogens, such as Listeria monocytogenes, are detected in the cytosol of host immune cells. Induction of this host response is often dependent on microbial secretion systems and, in L. monocytogenes, is dependent on multidrug efflux pumps (MDRs). Using L. monocytogenes mutants that overexpressed MDRs, we identified cyclic diadenosine monophosphate (c-di-AMP) as a secreted molecule able to trigger the cytosolic host response. Overexpression of the di-adenylate cyclase, dacA (lmo2120), resulted in elevated levels of the host response during infection. c-di-AMP thus represents a putative bacterial secondary signaling molecule that triggers a cytosolic pathway of innate immunity and is predicted to be present in a wide variety of bacteria and archea.

引用

页码：1703 / 1705

页数：3

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