Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

被引：470

作者：

Braasch, DA

Corey, DR ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

CHEMISTRY & BIOLOGY | 2001年 / 8卷 / 01期

关键词：

DNA recognition; locked nucleic acid; gene expression control; RNA recognition;

D O I：

10.1016/S1074-5521(00)00058-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1 / 7

页数：7

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