Cholinergic Signaling through Synaptic SK Channels: It's a Protein Kinase but Which One?

被引：9

作者：

Maylie, James ^{[2
]}

Adelman, John P. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97239 USA

来源：

NEURON | 2010年 / 68卷 / 05期

关键词：

METHYL-D-ASPARTATE; ACTIVATED POTASSIUM CHANNELS; SMALL-CONDUCTANCE; DENDRITIC SPINES; RAT HIPPOCAMPUS; ACETYLCHOLINE; PLASTICITY; RECEPTOR; MEMORY;

D O I：

10.1016/j.neuron.2010.11.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Cholinergic signaling modulates synaptic responses and influences cognition. In this issue of Neuron, two groups (Buchanan et al. and Giessel and Sabatini) present evidence that cholinergic signaling enhances postsynaptic responses in CM neurons by decreasing synaptic SK channel activity. However, they come to different conclusions about the protein kinases involved in this process.

引用

收藏

页码：809 / 811

页数：3

相关论文

共 20 条

[1]

Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexes [J].

Allen, Duane ;

Fakler, Bernd ;

Maylie, James ;

Adelman, John P. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (09) :2369-2376

[2]

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice [J].

Anagnostaras, SG ;

Murphy, GG ;

Hamilton, SE ;

Mitchell, SL ;

Rahnama, NP ;

Nathanson, NM ;

Silva, AJ .

NATURE NEUROSCIENCE, 2003, 6 (01) :51-58

[3]

Nonlinear regulation of unitary synaptic signals by CaV2.3 voltage-sensitive calcium channels located in dendritic spines [J].

Bloodgood, Brenda L. ;

Sabatini, Bernardo L. .

NEURON, 2007, 53 (02) :249-260

[4]

Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors Is Mediated by Inhibition of SK Channels [J].

Buchanan, Katherine A. ;

Petrovic, Milos M. ;

Chamberlain, Sophie E. L. ;

Marrion, Neil V. ;

Mellor, Jack R. .

NEURON, 2010, 68 (05) :948-963

[5]

M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK Channels [J].

Giessel, Andrew J. ;

Sabatini, Bernardo L. .

NEURON, 2010, 68 (05) :936-947

[6]

Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity [J].

Hammond, RS ;

Bond, CT ;

Strassmaier, T ;

Ngo-Ahn, TJ ;

Adelman, JP ;

Maylie, J ;

Stackman, RW .

JOURNAL OF NEUROSCIENCE, 2006, 26 (06) :1844-1853

[7]

High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation [J].

Hasselmo, ME ;

McGaughy, J .

ACETYLCHOLINE IN THE CEREBRAL CORTEX, 2004, 145 :207-231

[8]

Small-conductance, calcium-activated potassium channels from mammalian brain [J].

Kohler, M ;

Hirschberg, B ;

Bond, CT ;

Kinzie, JM ;

Marrion, NV ;

Maylie, J ;

Adelman, JP .

SCIENCE, 1996, 273 (5282) :1709-1714

[9]

SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses [J].

Lin, Mike T. ;

Lujan, Rafael ;

Watanabe, Masahiko ;

Adelman, John P. ;

Maylie, James .

NATURE NEUROSCIENCE, 2008, 11 (02) :170-177

[10]

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells [J].

Marino, MJ ;

Rouse, ST ;

Levey, AI ;

Potter, LT ;

Conn, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) :11465-11470