Homozygous deletions at 3p12 in breast and lung cancer

被引：90

作者：

Sundaresan, V

Chung, G

Heppell-Parton, A

Xiong, J

Grundy, C

Roberts, I

James, L

Cahn, A

Bench, A

Douglas, J

Minna, J

Sekido, Y

Lerman, M

Latif, F

Bergh, J

Li, H

Lowe, N

Ogilvie, D

Rabbitts, P

机构：

[1] Med Res Council Ctr, Macclesfield SK10 4TG, Cheshire, England

[2] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

[3] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75235 USA

[4] NCI, Frederick Canc Res Facil, Immunobiol Lab, Frederick, MD 21701 USA

[5] Univ Uppsala, Akad Sjukhuset, Dept Oncol, S-75185 Uppsala, Sweden

来源：

ONCOGENE | 1998年 / 17卷 / 13期

关键词：

DUTT1/Hrobo-1; lung cancer; U2020; deletion; tumour suppressor gene; familial non-specific dementia;

D O I：

10.1038/sj.onc.1202103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.

引用

页码：1723 / 1729

页数：7

共 31 条

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