Synthesis and anticancer effect of B-ring trifluoromethylated flavonoids

被引：55

作者：

Zheng, X

Cao, JG

Meng, WD

Qing, FL

机构：

[1] Donghua Univ, Coll Chem & Chem Engn, Shanghai 200051, Peoples R China

[2] Nanhua Univ, Inst Canc Res, Hengyang 521001, Hunan, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(03)00752-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of B-ring trifluoromethylated flavonoids derivatives were prepared and tested in vitro against human gastric adenocarcinoma cell line (SGC-7901). Among these derivatives, 5,7-dipropoxy-2-(4'-trifluoromethylphenyl)-chromen-4-one 5c had the strongest activity against SGC-7901 cell. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3423 / 3427

页数：5

共 17 条

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