Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

被引：59

作者：

Jiang, Hai ^{[2
]}

Shi, Jing ^{[1
]}

Li, Yuanyuan ^{[1
]}

机构：

[1] Zhejiang Med Coll, Dept Pharm, Hangzhou 310053, Zhejiang, Peoples R China

[2] Zhejiang Univ, Dept Urol, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

MOLECULES | 2011年 / 16卷 / 04期

关键词：

aromatase; Atractylodes macrocephala; atractylenolide; RECEPTOR MODULATORS SERMS; BREAST-CANCER; RHIZOMES;

D O I：

10.3390/molecules16043146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 +/- 0.70%, 90.93 +/- 1.41% and 86.31 +/- 8.46%, respectively, at a concentration of 10 mu M. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.

引用

页码：3146 / 3151

页数：6

共 16 条

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