Rifampicin antibiotic impregnation of the St Jude Medical mechanical valve sewing ring: A weapon against endocarditis

被引:12
作者
French, BG
Wilson, K
Wong, M
Smith, S
OBrien, MF
机构
[1] PRINCE CHARLES HOSP,DEPT CARDIAC SURG,BRISBANE,QLD 4032,AUSTRALIA
[2] PRINCE CHARLES HOSP,DEPT MICROBIOL,BRISBANE,QLD 4032,AUSTRALIA
关键词
D O I
10.1016/S0022-5223(96)70245-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The Dacron sewing ring material of the St, Jude Medical mechanical heart valve (St, Jude Medical, Inc., St, Paul, Minn.) was passively impregnated with rifampicin (60 mg/ml) both in its unsealed state and after sealing by the methods of preclotting in blood, autoclaving in blood, and autoclaving in 20% albumin. Antistaphylococcal activity in the Dacron material was assessed immediately after rifampicin impregnation and at regular periods up to 5 days after implantation into the goat aorta, When the Dacron material had been sealed by autoclaving in blood and autoclaving in 20% albumin significant retention of antistaphylococcal activity was found after 5 days in vivo, Best results were obtained with the use of autoclaved blood (p < 0.05), We also compared these results with those obtained from impregnating commercially available gelatin sealed (Gelseal) and collagen-sealed (Hemashield) Dacron material with rifampicin, Although anti-staphylococcal activity was equivalent immediately after rifampicin impregnation, after 4 days in vivo the activity was negligible in Gelseal material (p < 0.05) and could not be demonstrated in Hemashield material, Rifampicin impregnation of the intact St, Jude Medical mechanical valve sewing ring may have an application in the prevention of prosthetic valve endocarditis and a clinical protocol is suggested.
引用
收藏
页码:248 / 252
页数:5
相关论文
共 14 条
[1]  
ASHTON TR, 1990, P SOC BIOMATER, V13, P235
[2]  
AVRAMOVIC J, 1992, J CARDIOVASC SURG, V33, P70
[3]   RIFAMPICIN IMPREGNATION OF A PROTEIN-SEALED DACRON GRAFT - AN INFECTION-RESISTANT PROSTHETIC VASCULAR GRAFT [J].
AVRAMOVIC, JR ;
FLETCHER, JP .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 1991, 61 (06) :436-440
[4]  
CHERVU A, 1991, J VASC SURG, V13, P897
[5]   USE OF AN ANTIBIOTIC-BONDED GRAFT FOR INSITU RECONSTRUCTION AFTER PROSTHETIC GRAFT INFECTIONS [J].
COLBURN, MD ;
MOORE, WS ;
CHVAPIL, M ;
GELABERT, HA ;
QUINONESBALDRICH, WJ .
JOURNAL OF VASCULAR SURGERY, 1992, 16 (04) :651-660
[6]  
FREYRIE A, 1992, INT ANGIOL, V11, P113
[7]   TREATMENT OF VASCULAR GRAFT INFECTION BY IN-SITU REPLACEMENT WITH A RIFAMPIN-BONDED GELATIN-SEALED DACRON GRAFT [J].
GOEAUBRISSONNIERE, O ;
MERCIER, F ;
NICOLAS, MH ;
BACOURT, F ;
COGGIA, M ;
LEBRAULT, C ;
PECHERE, JC .
JOURNAL OF VASCULAR SURGERY, 1994, 19 (04) :739-744
[8]  
HAYDOCK D, 1992, J THORAC CARDIOV SUR, V103, P130
[9]   PROSTHETIC VALVE ENDOCARDITIS [J].
IVERT, TSA ;
DISMUKES, WE ;
COBBS, CG ;
BLACKSTONE, EH ;
KIRKLIN, JW ;
BERGDAHL, LAL .
CIRCULATION, 1984, 69 (02) :223-232
[10]   ANTIBACTERIAL ACTIVITY, ANTIBIOTIC RETENTION, AND INFECTION-RESISTANCE OF A RIFAMPIN-IMPREGNATED GELATIN-SEALED DACRON GRAFT [J].
LACHAPELLE, K ;
GRAHAM, AM ;
SYMES, JF .
JOURNAL OF VASCULAR SURGERY, 1994, 19 (04) :675-682