In vitro study of some medicinally important Mannich bases derived from antitubercular agent

被引：118

作者：

Joshi, S ^{[1
]}

Khosla, N ^{[1
]}

Tiwari, P ^{[1
]}

机构：

[1] Devi Ahilya Vishwavidyalaya, Sch Chem Sci, Indore, Madhya Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 03期

关键词：

isonicotinylhydrazide; sulphonamides; Mannich bases; antibacterial activity; toxicity; statistical analysis;

D O I：

10.1016/j.bmc.2003.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, H-1 nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：571 / 576

页数：6

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