Model selection methodology for inter-laboratory standardisation of antibody titres

被引：25

作者：

Kafatos, G

Andrews, N

Nardone, A

机构：

[1] Hlth Protech Agcy Ctr Infect, Stat Unit, Commun Dis Surveillance Ctr, London NW9 5EQ, England

[2] Hlth Protech Agcy Ctr Infect, Immunisat Dept, Commun Dis Surveillance Ctr, London NW9 5EQ, England

来源：

VACCINE | 2005年 / 23卷 / 42期

关键词：

sero-epidemiology; standardisation equation; assay comparison;

D O I：

10.1016/j.vaccine.2005.05.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of the European Sero-Epidemiology Network 2 (ESEN2) is to compare standardised serological results of vaccine preventable diseases across Europe. In order to adjust for laboratory and assay differences, the participant laboratories tested a standardisation panel for each disease and the results were plotted against those of a reference centre in order to obtain standardisation equations. We describe an algorithm for obtaining these equations which took into account outliers, censored data and model selection, and needed to be robust due to the variety of assays and diseases under investigation. If the standardisation equations explained sufficient variability, these were used to convert each country's main serum bank results to a common unitage, thereby allowing international comparisons to be made. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5022 / 5027

页数：6

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