Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease

被引：53

作者：

Alvira, Daniel ^{[1
,2
]}

Ferrer, Isidre

Gutierrez-Cuesta, Javier ^{[1
,2
]}

Garcia-Castro, Beatriz ^{[1
,2
]}

Pallas, Merce ^{[1
,2
]}

Camins, Antoni ^{[1
,2
]}

机构：

[1] Univ Barcelona, Nucl Univ Pedralbes, Unitat Farmacol & Farmacognosia, Fac Farm, E-08028 Barcelona, Spain

[2] Univ Barcelona, Inst Biomed IBUB, Nucl Univ Pedralbes, Fac Farm, E-08028 Barcelona, Spain

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 04期

关键词：

Parkinson's disease; cdk5; E2F-1; cell cycle;

D O I：

10.1016/j.parkreldis.2007.09.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：309 / 313

页数：5

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