What the Halted Phase III γ-Secretase Inhibitor Trial May (or May Not) Be Telling Us

被引：82

作者：

Schor, Nina F. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Pediat, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA

[3] Univ Rochester, Med Ctr, Dept Neurobiol & Anat, Rochester, NY 14642 USA

[4] Golisano Childrens Hosp, Rochester, NY USA

来源：

ANNALS OF NEUROLOGY | 2011年 / 69卷 / 02期

关键词：

P75 NEUROTROPHIN RECEPTOR; GROWTH-FACTOR RECEPTOR; ALZHEIMERS-DISEASE; MOUSE-BRAIN; EXPRESSION; APOPTOSIS; CELLS; PROTECTION; SCIENCE; COMPLEX;

D O I：

10.1002/ana.22365

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aborted trial of semagacestat has led some to invoke unanticipated effects of gamma-secretase inhibition on formation of amyloid beta. However, the many substrates for gamma-secretases and the varied biological effects of each of the resultant cleavage products make ascribing causality much more complex than that. ANN NEUROL 2011;69:237-239

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页码：237 / 239

页数：3

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