Understanding the MIG6-EGFR Signaling Axis in Lung Tumorigenesis

被引：10

作者：

Izumchenko, Evgeny ^{[1
]}

Sidransky, David ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Div Head & Neck Canc Res, Baltimore, MD 21231 USA

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 05期

关键词：

GROWTH-FACTOR RECEPTOR; EGF RECEPTOR; MIG6; HOMEOSTASIS; INHIBITION;

D O I：

10.1158/2159-8290.CD-15-0336

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

With multiple clinical trials under way targeting mutant EGFR in patients with lung cancer, Maity and colleagues address important aspects of a MIG6-EGFR signaling axis using genetically engineered mouse models expressing mutated EGFRs on the MIG6-deficient background. This study extends our understanding of EGFR regulation by MIG6 and reveals that MIG6 antagonizes tumor formation in mutant EGFR-driven lung adenocarcinoma. (C) 2015 AACR.

引用

页码：472 / 474

页数：3

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