Elevated corticotropin releasing hormone/corticotropin releasing hormone-R1 expression in postmortem brain obtained from children with generalized epilepsy

被引：29

作者：

Wang, W

Dow, KE

Fraser, DD

机构：

[1] Kingston Gen Hosp, Dept Paediat, Kingston, ON K7L 2V7, Canada

[2] Queens Univ, Dept Anat & Cell Biol, Kingston, ON, Canada

来源：

ANNALS OF NEUROLOGY | 2001年 / 50卷 / 03期

关键词：

D O I：

10.1002/ana.1138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The corticotropin releasing hormone (CRH) system has been suggested to initiate seizure activity in the developing brain. However, human data to support this theory is lacking. In this study, we have demonstrated that the expression of CRH, CRH-binding protein, and CRH-R1 (a CRH membrane receptor) were significantly elevated in cortical tissue obtained from 6 children with generalized epilepsy (mean age 8.2 +/- 1.5 years) relative to age-matched controls (mean age 7.8 +/- 1.4 years). In contrast, no significant difference in the expression of CRH-R2 was observed. The advent of CRH-R1 receptor antagonists may prove useful as novel anticonvulsants.

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页码：404 / 409

页数：6

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