Pteridine and nitrite/nitrate formation in experimental septic and traumatic shock

被引：14

作者：

Strohmaier, W ^{[1
]}

Werner, ER ^{[1
]}

Wachter, H ^{[1
]}

Redl, H ^{[1
]}

Schlag, G ^{[1
]}

机构：

[1] INST MED CHEM & BIOCHEM,INNSBRUCK,AUSTRIA

来源：

SHOCK | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1097/00024382-199610000-00005

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Bacterial lipopolysaccharides (LPS) induce the activity of guanosine triphosphate (GTP)-cyclohydrolase I (GTP-CHI), the first enzyme in the biosynthesis of tetrahydrobiopterin (H(4)bip) from GTP in endothelial cells and macrophages. In these and other cells, LPS also acts costimulatory with cytokines, i.e., mainly tumor necrosis factor-alpha (TNF-alpha), H(4)bip is the cofactor for nitric oxide synthase (NOS), We were interested in comparing the pteridine and nitrate levels in two baboon models: a hyperdynamic sepsis model and a hemorrhagic traumatic shock model. Our results show a similar response of pteridines (H(4)bip, neopterin) and nitrite/nitrate levels to an immune stimulus, LPS, which peaks rapidly, induces a sustained increase in pteridine levels in septic animals. Since hemorrhagic animals show very little response in terms of cytokine production, it was not possible to measure the induction of neopterin and nitrite/nitrate. This information could aid our understanding of the regulatory mechanisms in various forms of experimental shock.

引用

页码：254 / 258

页数：5

共 26 条

[1] LETS AGREE ON TERMINOLOGY - DEFINITIONS OF SEPSIS [J].