Mitochondrial fission and fusion dynamics: the long and short of it

被引：124

作者：

Berman, S. B. ^{[1
,2
,3
]}

Pineda, F. J. ^{[4
,5
]}

Hardwick, J. M. ^{[3
,4
]}

机构：

[1] Univ Pittsburgh, Pittsburgh Inst Neurodegenerat Dis, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2008年 / 15卷 / 07期

关键词：

mitochondria; fusion; fission; Drp1; Fis1; Fzo1;

D O I：

10.1038/cdd.2008.57

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintenance of functional mitochondria requires fusion and fission of these dynamic organelles. The proteins that regulate mitochondrial dynamics are now associated with a broad range of cellular functions. Mitochondrial fission and fusion are often viewed as a finely tuned balance within cells, yet an integrated and quantitative understanding of how these processes interact with each other and with other mitochondrial and cellular processes is not well formulated. Direct visual observation of mitochondrial fission and fusion events, together with computational approaches promise to provide new insight.

引用

页码：1147 / 1152

页数：6

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