Transcriptional regulation: Cancer, neurons and the REST

被引:128
作者
Coulson, JM
机构
[1] Univ Liverpool, Sch Biomed Sci, Physiol Lab, Liverpool L69 3BX, Merseyside, England
[2] Univ Liverpool, Sch Biomed Sci, Dept Human Anat & Cell Biol, Liverpool L69 3BX, Merseyside, England
关键词
D O I
10.1016/j.cub.2005.08.032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
REST/NRSF was first identified as a transcriptional repressor of neuronal genes in non-neuronal cells. Recent studies have now revealed seemingly paradoxical roles for REST/NRSF in neurogenesis, neural plasticity, tumour suppression and cancer progression.
引用
收藏
页码:R665 / R668
页数:4
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