Effects of aspirin on human psychophysical tuning curves in forward and simultaneous masking

被引:17
作者
Beveridge, HA
Carlyon, RP
机构
[1] MRC,APPL PSYCHOL UNIT,CAMBRIDGE CB2 2EF,ENGLAND
[2] UNIV SUSSEX,EXPT PSYCHOL LAB,BRIGHTON BN1 9QG,E SUSSEX,ENGLAND
基金
英国惠康基金;
关键词
aspirin; salicylate; frequency selectivity; forward masking; simultaneous masking; psychophysical tuning curve; suppression;
D O I
10.1016/S0378-5955(96)00091-3
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Psychophysical tuning curves (PTCs) at 4 kHz were measured in forward and simultaneous masking under two experimental conditions: 1 h after listeners had ingested three 320 mg capsules of aspirin every 6 h for 3 days (3.84 g/day), and after an identical schedule of placebo ingestion. Aspirin and placebo allocation was double-blind. In addition to raising thresholds at several audiometric frequencies, aspirin elevated the tips and reduced the slopes of the PTCs, indicating a reduction in frequency selectivity. The aspirin-induced reduction in PTC slopes did not differ significantly between forward and simultaneous masking, nor did the overall reduction differ significantly between the low- and high-frequency side. However, a separate analysis of the data obtained in simultaneous masking indicated that the broadening in tuning caused by aspirin was greatest on the high-frequency side of the PTC.
引用
收藏
页码:110 / 118
页数:9
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