DRiPs solidify: progress in understanding endogenous MHC class I antigen processing

被引：125

作者：

Yewdell, Jonathan W. ^{[1
]}

机构：

[1] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA

来源：

TRENDS IN IMMUNOLOGY | 2011年 / 32卷 / 11期

关键词：

DEFECTIVE RIBOSOMAL PRODUCTS; CRYPTIC TRANSLATION PRODUCTS; T-CELL EPITOPES; MESSENGER-RNA; ENDOPLASMIC-RETICULUM; PROTEIN-SYNTHESIS; MAJOR SOURCE; PROTEASOMAL DEGRADATION; CYTOSOLIC PEPTIDES; CROSS-PRESENTATION;

D O I：

10.1016/j.it.2011.08.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defective ribosomal products (DRiPs) are a subset of rapidly degraded polypeptides that provide peptide ligands for major histocompatibility complex (MHC) class I molecules. Here, recent progress in understanding DRIP biogenesis is reviewed. These findings place DRiPs at the center of the MHC class I antigen processing pathway, linking immunosurveillance of viruses and tumors to mechanisms of specialized translation and cellular compartmentalization. DRiPs enable the immune system to rapidly detect alterations in cellular gene expression with great sensitivity.

引用

收藏

页码：548 / 558

页数：11

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