New research avenues in toxicology: 7-gas N-Gas model, toxicant suppressants, and genetic toxicology

被引:26
作者
Levin, BC
机构
关键词
combustion gases; N-Gas Model; toxicant suppressants; genetic toxicology; polyurethane foam;
D O I
10.1016/S0300-483X(96)03497-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Three research areas - a 7-gas N-Gas Model, toxicant suppressants, and genetic toxicology - are presented as new research approaches in toxicology. The current 6-gas N-Gas Model predicts the toxic potency of the combustion products of materials based on the toxicological interactions of the fire gases carbon monoxide (GO), carbon dioxide (CO2), low oxygen (O-2) concentrations, hydrogen cyanide (HCN), hydrogen chloride, and hydrogen bromide. The present research includes nitrogen dioxide (NO2) in a new 7-gas model which incorporates the synergistic effects of NO2 and CO2, the antagonistic effects of NO2 and HCN, and the additive effects of NO2 with CO and low O-2. The area of toxicant suppressants concerns chemicals, which when added to a material, will inhibit or reduce the concentration of a specific toxic gas normally generated during thermal decomposition of that material. The effectiveness of this approach was demonstrated at the US National Institute of Standards and Technology when HCN generation was reduced by 90% and the resultant toxicity of the combustion products was lowered by 50% when a flexible polyurethane (FPU) foam was treated with 0.1% (by weight) cuprous oxide (Cu2O). Although melamine-treated FPU foams are being promoted as more fire safe than standard foams, a melamine-treated foam generated 10 times more HCN than a foam without melamine. The addition of Cu2O to this melamine foam also reduced the HCN generation by 90%. The genetic toxicology research entails the examination of DNA damage that results from the exposure of human cells to various environmental toxicants and gases.
引用
收藏
页码:89 / 106
页数:18
相关论文
共 41 条
[1]  
AUSUBEL FM, 1993, DNA SEQUENCING, V1, pCH7
[2]  
Babrauskas V., 1991, TOXIC POTENCY MEASUR, V827
[3]  
Braun E., 1991, 1284 NIST
[4]  
BRAUN E, 1988, PUBLICATION NBSIR
[5]  
BRAUN E, 1987, PUBLICATION NBSIR
[6]  
DIGIORGIO C, 1994, CARCINOGENESIS, V15, P313
[7]   DAMAGE TO THE DNA BASES IN MAMMALIAN CHROMATIN BY HYDROGEN-PEROXIDE IN THE PRESENCE OF FERRIC AND CUPRIC IONS [J].
DIZDAROGLU, M ;
RAO, G ;
HALLIWELL, B ;
GAJEWSKI, E .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 285 (02) :317-324
[8]  
FRENCH M, 1994, CARCINOGENESIS, V15, P1405
[9]  
FRESHNEY RI, 1987, CULTURE ANIMAL CELLS, P246
[10]  
GOLDSTEIN E, 1980, NITROGEN OXIDES THEI, P143