Molecular forms of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with senile dementia of the Alzheimer type

被引:12
作者
Strittmatter, M
Cramer, H
Reuner, C
Strubel, D
Hamann, G
Schimrigk, K
机构
[1] UNIV FREIBURG, DEPT NEUROL, D-79110 FREIBURG, GERMANY
[2] UNIV STRASBOURG, DEPT GERIATR, STRASBOURG, FRANCE
关键词
SDAT; dementia; CSF; somatostatin; somatostatin-14;
D O I
10.1016/S0006-3223(96)00211-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the cerebrospinal fluid (CSF) of 53 patients with senile dementia of the Alzheimer type (SDAT) and 12 elderly controls, we measured somatostatin (SLI) and its molecular forms: high-molecular weight form (HMV-SST), somatostatin-14 (SST-14), somatostatin-25/28 (SST-28/25), and des-ala-somatostatin (des-ala-SST) using high pressure liquid choromatography (HPLC) and a radioimmunoassay. In SDAT, SLI was significantly decreased (p <0.05) and correlated with dementia scores (r=-0.65, p <0.05). HPLC separation showed a marked heterogeneity of SLI in the CSF with a preponderance of SST-14 and SST-25/28. The significant loss of SST-14 (p <0.05) in SDAT was found to be correlated with dementia scores (r=0.65). Moreover, qualitative and quantitative changes in the molecular pattern of SLI in SDAT indicated dysregulated synthesis and/or processing of somatostatin relating to the severity of dementia. The long-term administration of neuroleptics in severe cases of SDAT caused a significant increase of SLI (p <0.05) and influenced the ratio of HMV-SST/SST-14 and SST25/28/SST-14. (C) 1997 Society of Biological Psychiatry.
引用
收藏
页码:1124 / 1130
页数:7
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