Comparison of Polymyxin B, Tigecycline, Cefepime, and Meropenem MICs for KPC-Producing Klebsiella pneumoniae by Broth Microdilution, Vitek 2, and Etest

被引：52

作者：

Lat, Asma ^{[1
]}

Clock, Sarah A. ^{[2
]}

Wu, Fann ^{[2
]}

Whittier, Susan

Della-Latta, Phyllis ^{[2
]}

Fauntleroy, Kathy ^{[3
]}

Jenkins, Stephen G. ^{[3
]}

Saiman, Lisa ^{[2
]}

Kubin, Christine J. ^{[2
]}

机构：

[1] Columbia Univ, Med Ctr, New York Presbyterian Hosp, Dept Pharm, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, New York, NY 10032 USA

[3] Weill Cornell Med Coll, New York, NY USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 05期

关键词：

ANTIMICROBIAL SURVEILLANCE PROGRAM; IN-VITRO ACTIVITY; NEW-YORK; BETA-LACTAMASE; EPIDEMIOLOGY; INFECTION; BROOKLYN;

D O I：

10.1128/JCM.02534-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report MIC agreement and error rates between broth microdilution (BMD), Vitek 2, and Etest against 48 clinical KPC-producing Klebsiella pneumoniae isolates for polymyxin B, tigecycline, cefepime, and meropenem. Both commercial testing methods were useful for tigecycline testing; Etest provided a conservative estimate of polymyxin B susceptibility. We suggest that laboratories consider the supplemental use of reference BMD or Etest for cefepime and meropenem for susceptibility testing of KPC-producing K. pneumoniae, as Vitek 2 did not provide reliable results.

引用

页码：1795 / 1798

页数：4

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