Mutant C57Bl/KsLeprdb/+ mice as a genetic model of type 2 diabetes mellitus

被引：8

作者：

Stepanova, O. I. ^{[1
]}

Karkischenko, N. N. ^{[1
]}

Baranova, O. V. ^{[1
]}

Galahova, T. V. ^{[1
]}

Semenov, X. X. ^{[1
]}

Beskova, T. B. ^{[1
]}

Stepanova, E. A. ^{[2
]}

Zakir'yanov, A. R. ^{[2
]}

Onischenko, N. A. ^{[2
]}

机构：

[1] Russian Acad Med Sci, Res Ctr Biomed Technol, Moscow, Russia

[2] Res Inst Transplantol & Artificial Organs, Fed Agcy Hlth Care & Social Dev, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 144卷 / 06期

关键词：

type 2 diabetes mellitus; db/db mice; experimental model;

D O I：

10.1007/s10517-007-0438-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The genetic model of diabetes mellitus was studied on mutant C57Bl/KsLepr(db/+) mice. These mice were characterized by high concentrations of glucose and glycosylated hemoglobin in the blood, polyuria, polyphagia, polydipsia, progressive obesity, biphasic morphological changes in insular islets of the pancreas (hyperplasia and atrophy), fatty degeneration of the liver, and hypoplasia of the spleen tissue and lymph nodes. Our results indicate that C57Bl/KsLepr(db/+) mice serve as an adequate model of type 2 diabetes mellitus. This model is suitable for testing of therapeutic methods for type 2 diabetes mellitus.

引用

页码：813 / 816

页数：4