The N-acylation-phosphodiesterase pathway and cell signalling

被引：146

作者：

Schmid, HHO ^{[1
]}

Schmid, PC ^{[1
]}

Natarajan, V ^{[1
]}

机构：

[1] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN 46202

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1996年 / 80卷 / 1-2期

关键词：

N-acylethanolamine; N-acyl PE; anandamide; cannabinoid receptor; phospholipase D; signal transduction;

D O I：

10.1016/0009-3084(96)02554-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-chain N-acylethanolamines (NAEs) elicit a variety of biological and pharmacological effects. Anandamide (20:4n-6 NAE) and other polyunsaturated NAEs bind to the cannabinoid receptor and may thus serve as highly specific lipid mediators of cell signalling. NAEs can be: formed by phospholipase D-catalyzed hydrolysis of N-acylethanolamine phospholipids or by direct condensation of ethanolamine and fatty acid. So far, most of the latter biosynthetic activity has been shown to be the reverse reaction of the NAE amidohydrolase that catalyzes NAE degradation. Thus, increasing evidence supports the hypothesis that the iv-acylation-phosphodiesterase pathway yields not only saturated-monounsaturated NAEs, but polyunsaturated ones, including anandamide, as well.

引用

页码：133 / 142

页数：10

共 64 条

[1] N-ACYLETHANOLAMINES AS MEMBRANE TOPOLOGICAL STRESS COMPROMISING AGENTS [J].