Transmembrane proteins of tight junctions

被引：381

作者：

Chiba, Hideki ^{[1
]}

Osanai, Makoto ^{[1
]}

Murata, Masaki ^{[1
]}

Kojima, Takashi ^{[1
]}

Sawada, Norimasa ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Pathol, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2008年 / 1778卷 / 03期

关键词：

tight junction; cell junction; cell polarity; claudin; occludin; junctional adhesion molecule;

D O I：

10.1016/j.bbamem.2007.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes, and signal transduction, acting as a multifunctional complex in vertebrate epithelial and endothelial cells. The identification and characterization of the transmembrane proteins of tight junctions, claudins, junctional adhesion molecules (JAMs), occludin and tricellulin, have led to insights into the molecular nature of tight junctions. We provide an overview of recent progress in studies on these proteins and highlight their roles and regulation, as well as their functional significance in human diseases. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：588 / 600

页数：13

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