O-benzyl hydroxyproline as a bioisostere for Phe-Pro: Novel dipeptide thrombin inhibitors

被引：18

作者：

Klein, SI ^{[1
]}

Dener, JM ^{[1
]}

Molino, BF ^{[1
]}

Gardner, CJ ^{[1
]}

DAlisa, R ^{[1
]}

Dunwiddie, CT ^{[1
]}

Kasiewski, C ^{[1
]}

Leadley, RJ ^{[1
]}

机构：

[1] RHONE POULENC RORER, DEPT CARDIOVASC BIOL, COLLEGEVILLE, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 18期

关键词：

D O I：

10.1016/0960-894X(96)00404-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-ho dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2225 / 2230

页数：6

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