Palladium-Catalyzed Direct Arylation of Heteroaromatic Compounds: Improved Conditions Utilizing Controlled Microwave Heating

被引：116

作者：

Baghbanzadeh, Mostafa ^{[1
,2
]}

Pilger, Christian ^{[3
]}

Kappe, C. Oliver ^{[1
,2
]}

机构：

[1] Karl Franzens Univ Graz, CDLMC, A-8010 Graz, Austria

[2] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

[3] BASF SE, D-67056 Ludwigshafen, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 19期

关键词：

METALATION-DEPROTONATION MECHANISM; CROSS-COUPLING REACTIONS; SILICON-CARBIDE; ARYL HALIDES; HETEROARENES; DERIVATIVES; CYCLIZATION; FUNCTIONALIZATION; ACTIVATION; INHIBITORS;

D O I：

10.1021/jo201516v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile and rapid microwave-assisted procedure for the palladium-catalyzed direct arylation of heterocycles by aryl bromides and heteroaryl bromides is described. This novel protocol features short coupling times (10-60 min) and low catalyst loadings (1 mol %) and allows the successful arylation of previously unreactive heterocyclic substrates.

引用

页码：8138 / 8142

页数：5

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