1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors

被引:68
作者
Bihovsky, R [1 ]
Tao, M [1 ]
Mallamo, JP [1 ]
Wells, GJ [1 ]
机构
[1] Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA
关键词
D O I
10.1016/j.bmcl.2003.11.037
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of potent 1,2-benzothiazine 1,1-dioxide alpha-ketoamide inhibitors of calpain I is described. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1035 / 1038
页数:4
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