共 20 条
1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors
被引:68
作者:

Bihovsky, R
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA

Tao, M
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA

Mallamo, JP
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA

Wells, GJ
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA
机构:
[1] Cephalon Inc, Dept Med Chem, W Chester, PA 19380 USA
关键词:
D O I:
10.1016/j.bmcl.2003.11.037
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
A series of potent 1,2-benzothiazine 1,1-dioxide alpha-ketoamide inhibitors of calpain I is described. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1035 / 1038
页数:4
相关论文
共 20 条
[1]
ALPHA-DIKETONE AND ALPHA-KETO ESTER DERIVATIVES OF N-PROTECTED AMINO-ACIDS AND PEPTIDES AS NOVEL INHIBITORS OF CYSTEINE AND SERINE PROTEINASES
[J].
ANGELASTRO, MR
;
MEHDI, S
;
BURKHART, JP
;
PEET, NP
;
BEY, P
.
JOURNAL OF MEDICINAL CHEMISTRY,
1990, 33 (01)
:11-13

ANGELASTRO, MR
论文数: 0 引用数: 0
h-index: 0
机构:
MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215 MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215

MEHDI, S
论文数: 0 引用数: 0
h-index: 0
机构:
MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215 MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215

BURKHART, JP
论文数: 0 引用数: 0
h-index: 0
机构:
MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215 MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215

PEET, NP
论文数: 0 引用数: 0
h-index: 0
机构:
MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215 MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215

BEY, P
论文数: 0 引用数: 0
h-index: 0
机构:
MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215 MERRELL DOW RES INST,2110 E GALBRAITH RD,CINCINNATI,OH 45215
[2]
The calpain hypothesis of neurodegeneration: Evidence for a common cytotoxic pathway
[J].
Bartus, RT
.
NEUROSCIENTIST,
1997, 3 (05)
:314-327

Bartus, RT
论文数: 0 引用数: 0
h-index: 0
机构:
TUFTS UNIV, MED CTR, BOSTON, MA 02111 USA TUFTS UNIV, MED CTR, BOSTON, MA 02111 USA
[3]
Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I
[J].
Chatterjee, S
;
Ator, MA
;
BozyczkoCoyne, D
;
Josef, K
;
Wells, G
;
Tripathy, R
;
Iqbal, M
;
Bihovsky, R
;
Senadhi, SE
;
Mallya, S
;
OKane, T
;
McKenna, BA
;
Siman, R
;
Mallamo, JP
.
JOURNAL OF MEDICINAL CHEMISTRY,
1997, 40 (23)
:3820-3828

Chatterjee, S
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Ator, MA
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

BozyczkoCoyne, D
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Josef, K
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Wells, G
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Tripathy, R
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Iqbal, M
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Bihovsky, R
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Senadhi, SE
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Mallya, S
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

OKane, T
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

McKenna, BA
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Siman, R
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Mallamo, JP
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380
[4]
Exploration of the importance of the P2-P3 -NHCO-moiety in a potent Di- or tripeptide inhibitor of calpain I:: Insights into the development of nonpeptidic inhibitors of calpain I
[J].
Chatterjee, S
;
Iqbal, M
;
Mallya, S
;
Senadhi, SE
;
O'Kane, TM
;
McKenna, BA
;
Bozyczko-Coyne, D
;
Kauer, JC
;
Siman, R
;
Mallamo, JP
.
BIOORGANIC & MEDICINAL CHEMISTRY,
1998, 6 (05)
:509-522

Chatterjee, S
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Iqbal, M
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Mallya, S
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Senadhi, SE
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

O'Kane, TM
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

McKenna, BA
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Bozyczko-Coyne, D
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Kauer, JC
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Siman, R
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Mallamo, JP
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA
[5]
P2-achiral, P'-extended α-ketoamide inhibitors of calpain I
[J].
Chatterjee, S
;
Dunn, D
;
Tao, M
;
Wells, G
;
Gu, ZQ
;
Bihovsky, R
;
Ator, MA
;
Siman, R
;
Mallamo, JP
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
1999, 9 (16)
:2371-2374

Chatterjee, S
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Dunn, D
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Tao, M
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Wells, G
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Gu, ZQ
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Bihovsky, R
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Ator, MA
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Siman, R
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA

Mallamo, JP
论文数: 0 引用数: 0
h-index: 0
机构:
Cephalon Inc, W Chester, PA 19380 USA Cephalon Inc, W Chester, PA 19380 USA
[6]
D-amino acid containing, high-affinity inhibitors of recombinant human calpain I
[J].
Chatterjee, S
;
Gu, ZQ
;
Dunn, D
;
Tao, M
;
Josef, K
;
Tripathy, R
;
Bihovsky, R
;
Senadhi, SE
;
O'Kane, TM
;
McKenna, BA
;
Mallya, S
;
Ator, MA
;
Bozyczko-Coyne, D
;
Siman, R
;
Mallamo, JP
.
JOURNAL OF MEDICINAL CHEMISTRY,
1998, 41 (15)
:2663-2666

Chatterjee, S
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Gu, ZQ
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Dunn, D
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Tao, M
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Josef, K
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Tripathy, R
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Bihovsky, R
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Senadhi, SE
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

O'Kane, TM
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

McKenna, BA
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Mallya, S
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Ator, MA
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Bozyczko-Coyne, D
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Siman, R
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA

Mallamo, JP
论文数: 0 引用数: 0
h-index: 0
机构: Cephalon Inc, Dept Chem, W Chester, PA 19380 USA
[7]
Potent fluoromethyl ketone inhibitors of recombinant human calpain I+
[J].
Chatterjee, S
;
Josef, K
;
Wells, G
;
Iqbal, M
;
Bihovsky, R
;
Mallamo, JP
;
Ator, MA
;
BozyczkoCoyne, D
;
Mallya, S
;
Senadhi, S
;
Siman, R
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
1996, 6 (11)
:1237-1240

Chatterjee, S
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Josef, K
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Wells, G
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Iqbal, M
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Bihovsky, R
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Mallamo, JP
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Ator, MA
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

BozyczkoCoyne, D
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Mallya, S
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Senadhi, S
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380

Siman, R
论文数: 0 引用数: 0
h-index: 0
机构:
CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380 CEPHALON INC,DEPT BIOCHEM,W CHESTER,PA 19380
[8]
Calpain and mitochondria in ischemia/reperfusion injury
[J].
Chen, M
;
Won, DJ
;
Krajewski, S
;
Gottlieb, RA
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2002, 277 (32)
:29181-29186

Chen, M
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

Won, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

Krajewski, S
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

Gottlieb, RA
论文数: 0 引用数: 0
h-index: 0
机构: Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[9]
STEREOSPECIFIC SYNTHESIS OF PEPTIDYL ALPHA-KETO AMIDES AS INHIBITORS OF CALPAIN
[J].
HARBESON, SL
;
ABELLEIRA, SM
;
AKIYAMA, A
;
BARRETT, R
;
CARROLL, RM
;
STRAUB, JA
;
TKACZ, JN
;
WU, CC
;
MUSSO, GF
.
JOURNAL OF MEDICINAL CHEMISTRY,
1994, 37 (18)
:2918-2929

HARBESON, SL
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

ABELLEIRA, SM
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

AKIYAMA, A
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

BARRETT, R
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

CARROLL, RM
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

STRAUB, JA
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

TKACZ, JN
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

WU, CC
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136

MUSSO, GF
论文数: 0 引用数: 0
h-index: 0
机构: Alkermes, Inc., Cambridge, Massachusetts 02139-4136
[10]
CHARACTERIZATION OF A CONTINUOUS FLUOROGENIC ASSAY FOR CALPAIN-I - KINETIC EVALUATION OF PEPTIDE ALDEHYDES, HALOMETHYL KETONES AND (ACYLOXY)METHYL KETONES AS INHIBITORS OF THE ENZYME
[J].
HARRIS, AL
;
GREGORY, JS
;
MAYCOCK, AL
;
GRAYBILL, TL
;
OSIFO, IK
;
SCHMIDT, SJ
;
DOLLE, RE
.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
1995, 5 (04)
:393-398

HARRIS, AL
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

GREGORY, JS
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

MAYCOCK, AL
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

GRAYBILL, TL
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

OSIFO, IK
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

SCHMIDT, SJ
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

DOLLE, RE
论文数: 0 引用数: 0
h-index: 0
机构:
STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426 STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426