Improving cancer immunotherapy by targeting the STATe of MDSCs

被引：59

作者：

de Haas, Nienke ^{[1
]}

de Koning, Coco ^{[1
,2
]}

Spilgies, Lisanne ^{[1
,3
]}

de Vries, I. Jolanda M. ^{[1
]}

Hato, Stanleyson V. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Inst Mol Life Sci, Dept Tumor Immunol, POB 9101, NL-6500 HB Nijmegen, Netherlands

[2] Univ Med Ctr Utrecht, Lab Translat Immunol, Utrecht, Netherlands

[3] Univ Zurich, Dept Expt Immunol, Zurich, Switzerland

来源：

ONCOIMMUNOLOGY | 2016年 / 5卷 / 07期

关键词：

Drugs; immunotherapy; MDSCs; STAT signaling; tumor microenvironment; RENAL-CELL CARCINOMA; TRANSCRIPTION FACTOR ACTIVITY; MYELOID SUPPRESSOR-CELLS; ANTITUMOR IMMUNITY; DENDRITIC CELLS; TUMOR-GROWTH; CHRONIC INFLAMMATION; NITRIC-OXIDE; T-CELLS; DIFFERENTIATION;

D O I：

10.1080/2162402X.2016.1196312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer immunotherapy is a promising therapeutic avenue; however, in practice its efficacy is hampered by an immunosuppressive tumor microenvironment that consists of suppressive cell types like myeloid-derived suppressor cells (MDSCs). Eradication or reprogramming of MDSCs could therefore enhance clinical responses to immunotherapy. Here, we review clinically available drugs that target MDSCs, often through inhibition of STAT signaling, which is essential for MDSC accumulation and suppressive functions. Interestingly, several drugs used for non-cancerous indications and natural compounds similarly inhibit MDSCs by STAT inhibition, but have fewer side effects than anticancer drugs. Therefore, they show great potential for combination strategies with immunotherapy.

引用

页数：11

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