Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations

被引：20

作者：

Blancher, Antoine ^{[1
]}

Aarnink, Alice ^{[1
]}

Tanaka, Keiko ^{[2
]}

Ota, Masao ^{[3
]}

Inoko, Hidetoshi ^{[2
]}

Yamanaka, Hisashi ^{[4
]}

Nakagawa, Hiroshi ^{[4
]}

Apoil, Pol-Andre ^{[1
]}

Shiina, Takashi ^{[2
]}

机构：

[1] Univ Toulouse 3, CHU Toulouse, Immunogenet Mol Lab, Fac Med Purpan,TSA,EA 3034, F-50032 Toulouse 9, France

[2] Tokai Univ, Dept Mol Life Sci, Div Basic Med Sci & Mol Med, Sch Med, Isehara, Kanagawa 2591143, Japan

[3] Shinshu Univ, Sch Med, Dept Legal Med, Matsumoto, Nagano 3908621, Japan

[4] Ina Res Inc, Ina, Nagano 3994501, Japan

来源：

IMMUNOGENETICS | 2012年 / 64卷 / 08期

基金：

日本学术振兴会;

关键词：

MHC; DRB; Cynomolgus macaque; Polymorphism; SEQUENCE VARIABILITY ANALYSIS; RHESUS; DIVERSITY; MACAQUES; INTROGRESSION; MULATTA; ORIGIN;

D O I：

10.1007/s00251-012-0613-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The cynomolgus macaque (Macaca fascicularis) is currently used as an animal model in various fields of immunology especially in the development of innovative vaccines for the prevention and treatment of infectious diseases. The polymorphism of the major histocompatibility complex (MHC) influences the development of adaptive immune responses, and it is crucial to characterize the polymorphism of cynomolgus MHC genes. Among all macaque species, the cynomolgus macaque has the most diversified geographical area encompassing continental and insular populations. By the study of a large sample of animals from the Philippines (N = 359), we have characterized 20 DRB haplotypes. The DRB genotyping was performed by denaturing gradient gel electrophoresis (DGGE) sequencing of exon 2 and was confirmed by polymerase chain reaction-sequence-specific oligonucleotide. The DRB and DRA cDNA of 126 animals were characterized by cloning and sequencing. By means of DGGE sequencing, we characterized the polymorphism of genomic DRB exon 2 in three other cynomolgus macaque population samples (Java, Vietnam, and Mauritius), and we discuss about the origin of the founders of the Mauritian and the Filipino cynomolgus macaque populations.

引用

页码：605 / 614

页数：10

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