Evidence of an association between Chlamydia pneumoniae and cerebrovascular accidents

被引:5
作者
Bucurescu, G
Stieritz, DD
机构
[1] Vet Affairs Med Ctr, Neurol Serv, Philadelphia, PA 19104 USA
[2] Vet Affairs Med Ctr, Pathol & Lab Med Serv, Philadelphia, PA 19104 USA
关键词
cerebrovascular accidents; Chlamydia pneumoniae; stroke;
D O I
10.1046/j.1468-1331.2003.00605.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors report results of a retrospective pilot study showing a strong association between patients with stroke/TIA and the presence of circulating IgG and IgA antibodies to Chlamydia pneumoniae. These results support the hypothesis that chronic active or persistent infection may play a role in the mechanism of thrombosis. The risk for stroke associated with Chlamydial circulating antibodies appeared to be independent of other risk factors such as diabetes and hypercholesterolemia.
引用
收藏
页码:449 / 452
页数:4
相关论文
共 14 条
[1]  
BASS, 2001, J CLIN MICROBIOL, V30, P1368
[2]   Performance of three microimmunofluorescence assays for detection of Chlamydia pneumoniae immunoglobulin M, G, and A antibodies [J].
Bennedsen, M ;
Berthelsen, L ;
Lind, I .
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2002, 9 (04) :833-839
[3]  
Bucurescu G, 2001, NEUROLOGY, V56, pA106
[4]   Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia - The West Birmingham Stroke Project [J].
Cook, PJ ;
Honeybourne, D ;
Lip, GYH ;
Beevers, DG ;
Wise, R ;
Davies, P .
STROKE, 1998, 29 (02) :404-410
[5]   Standardizing Chlamydia pneumoniae assays:: Recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada) [J].
Dowell, SF ;
Peeling, RW ;
Boman, J ;
Carlone, GM ;
Fields, BS ;
Guarner, J ;
Hammerschlag, MR ;
Jackson, LA ;
Kuo, CC ;
Maass, M ;
Messmer, TO ;
Talkington, DF ;
Tondella, ML ;
Zaki, SR ;
Bandea, C ;
Black, C ;
O'Conner, S ;
Papp, J ;
Perilla, MJ ;
Schuchat, A ;
Stevens, V ;
Van Beneden, CA ;
Zell, ER ;
Cohen, C ;
Campbell, LA ;
Wwang, SP ;
Grayston, JT ;
Deal, CD ;
Gaydos, C ;
Schindler, L ;
Taylor, CE ;
Mahony, J ;
Fong, IW ;
Leinonen, M ;
Saikku, P ;
Maas, M ;
Ossewaarde, JM ;
Persson, K ;
Boman, J ;
Apfalter, P .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (04) :492-502
[6]   Chlamydia pneumoniae and the risk of first ischemic stroke -: The Northern Manhattan Stroke Study [J].
Elkind, MSV ;
Lin, IF ;
Grayston, JT ;
Sacco, RL .
STROKE, 2000, 31 (07) :1521-1525
[7]   Chlamydia pneumoniae but not cytomegalovirus antibodies are associated with future risk of stroke and cardiovascular disease -: A prospective study in middle-aged to elderly men with treated hypertension [J].
Fagerberg, B ;
Gnarpe, J ;
Gnarpe, H ;
Agewall, S ;
Wikstrand, J .
STROKE, 1999, 30 (02) :299-305
[8]   Chlamydia pneumoniae antibodies and high lipoprotein(a) levels do not predict ischemic cerebral infarctions results from a nested case-control study in northern Sweden [J].
Glader, CA ;
Stegmayr, B ;
Boman, J ;
Stenlund, H ;
Weinehall, L ;
Hallmans, G ;
Dahlén, GH .
STROKE, 1999, 30 (10) :2013-2018
[9]   Chronic infections and the risk of carotid atherosclerosis - Prospective results from a large population study [J].
Kiechl, S ;
Egger, G ;
Mayr, M ;
Wiedermann, CJ ;
Bonora, E ;
Oberhollenzer, F ;
Muggeo, M ;
Xu, QB ;
Wick, G ;
Poewe, W ;
Willeit, J .
CIRCULATION, 2001, 103 (08) :1064-1070
[10]  
Motulsky H., 1995, INTUITIVE BIOSTATIST