A long-term seal- and cod-liver-oil supplementation in hypercholesterolemic subjects

被引:34
作者
Brox, J [1 ]
Olaussen, K
Osterud, B
Elvevoll, EO
Bjornstad, E
Brenn, T
Brattebo, G
Iversen, H
机构
[1] Univ Tromso Hosp, Dept Clin Chem, N-9038 Tromso, Norway
[2] Hammerfest Hosp, N-9600 Hammerfest, Norway
[3] Univ Tromso, Inst Med Biol, Dept Biochem, N-9037 Tromso, Norway
[4] Norwegian Inst Fisheries & Aquaqulture Ltd, N-9005 Tromso, Norway
[5] Univ Coll Finnmark, N-9500 Alta, Norway
[6] Univ Tromso, Inst Community Med, N-9037 Tromso, Norway
[7] Bergen Univ Hosp, N-5000 Bergen, Norway
关键词
D O I
10.1007/s11745-001-0661-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this long-term study, we wanted to explore the effect of dietary supplementation of seal oil (SO) as compared cod-liver oil (CLO) on subjects with moderate hypercholesterolemia, The test parameters included fatty acid composition in serum, blood lipids, platelet aggregation, and the activity of blood monocytes. After a run-in period of 6 mon, 120 clinically healthy hypercholesterolemic (7.0-9.5 mmol/L; 270-366 mg/dL) subjects were randomly selected to consume either 15 mi of SO or CLO daily for 14 mon followed by a 4-mon wash-out period. A third group was not given any dietary supplement (control). Consumption of marine oils (SO and CLO) changed the fatty acid composition of serum significantly. Maximal levels were achieved after 10 mon. No further changes were seen after 14 mon. A wash-out period of 4 mon hardly altered the level of n-3 fatty acids in serum. Addition of SO gave 30% higher level of eicosapentaenoic acid, as compared to CLO. Subjects taking SO or CLO had lower whole-blood platelet aggregation than the control group. Neither SO nor CLO had any effects on the levels of serum total cholesterol, high-density lipoprotein cholesterol, postprandial triacylglycerol, apolipoproteins A1 and B100, lipoprotein (a), monocyte function expressed as monocyte-derived tissue factor expression, and tumor necrosis factor.
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页码:7 / 13
页数:7
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