High throughput purification of combinatorial libraries

被引：34

作者：

Schultz, L ^{[1
]}

Garr, CD ^{[1
]}

Cameron, LM ^{[1
]}

Bukowski, J ^{[1
]}

机构：

[1] MDS Panlabs, Dept Chem, Bothell, WA 98011 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(98)00436-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This article summarizes recent advances at MDS Panlabs which provide for the high-throughput preparative HPLC purification of our Optiverse(TM) screening library. Topics covered include unique methods for the preparation, purification, characterization, and plating of purified screening compounds. Also discussed are procedures for data tracking as samples proceed through the purification process. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2409 / 2414

页数：6