Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice

被引：79

作者：

Liu, C-M ^{[1
]}

Yang, Z. ^{[1
]}

Liu, C-W ^{[1
]}

Wang, R. ^{[1
]}

Tien, P. ^{[1
]}

Dale, R. ^{[2
]}

Sun, L-Q ^{[2
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, Mol Virol Res Ctr, Beijing 100080, Peoples R China

[2] Oligos Etc Inc, Wilsonville, OR 97070 USA

来源：

GENE THERAPY | 2008年 / 15卷 / 03期

关键词：

myostatin; antisense; muscle wasting; cancer cachexia;

D O I：

10.1038/sj.gt.3303016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myostatin is a negative regulator of myogenesis, and inactivation of myostatin leads to muscle growth. Here we have used modified RNA oligonucleotides targeting the myostatin mRNA and examined the therapeutic potential in normal and cancer cachexia mouse models. We found that the RNA oligonucleotides could suppress the myostatin expression in vivo, leading to the increase in muscle growth both in normal and cachectic mice. We also established that the effect of myostatin inhibition caused by the RNA oligonucleotides may be through the MyoD pathway, as evidenced by a significant upregulation of MyoD expression. Taken together, these results demonstrate the feasibility using antisense strategy for the treatment of muscle wasting conditions.

引用

页码：155 / 160

页数：6

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