Morphing into cancer: The role of developmental signaling pathways in brain tumor formation

被引：75

作者：

Fogarty, MP ^{[1
]}

Kessler, JD ^{[1
]}

Wechsler-Reya, RJ ^{[1
]}

机构：

[1] Duke Univ, Ctr Med, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

JOURNAL OF NEUROBIOLOGY | 2005年 / 64卷 / 04期

关键词：

Hedgehog; Wnt; BMP; medulloblastoma; glioblastoma;

D O I：

10.1002/neu.20166

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Morphogens play a critical role in most aspects of development, including expansion and patterning of the central nervous system. Activating germline mutations in components of the Hedgehog and Wnt pathways have provided evidence for the important roles morphogens play in the genesis of brain tumors such as cerebellar medulloblastoma. In addition, aberrant expression of transforming growth factor-beta (TGF-beta) superfamily members has been demonstrated to contribute to progression of malignant gliomas. This review summarizes our current knowledge about the roles of morphogens in central nervous system tumorigenesis. (c) 2005 Wiley Periodicals, Inc.

引用

页码：458 / 475

页数：18

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