Intrathecal. administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury

被引：42

作者：

McAdoo, JD

Warner, DS

Goldberg, RN

Vitek, MP

Pearlstein, R

Laskowitz, DT

机构：

[1] Duke Univ, Med Ctr, Neonatal Perinatal Res Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Med Neurol, Durham, NC 27710 USA

[5] Cognosci Inc, Res Triangle Pk, NC 27709 USA

来源：

NEUROSCIENCE LETTERS | 2005年 / 381卷 / 03期

关键词：

apolipoprotein E; neuroprotection; hypoxia-ischemia; MK-801; perinatal hypoxia-ischemia;

D O I：

10.1016/j.neulet.2005.02.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Perinatal hypoxic-ischemic brain injury remains a significant clinical problem for which there remains no adequate therapeutic intervention. Apolipoprotein E (apoE) is a 299 amino acid protein that has been demonstrated to modify functional recovery following acute ischemic and traumatic brain injury. The aim of the current study was to evaluate whether administration of an apoE-derived peptide could reduce CNS injury in a rodent model of perinatal hypoxia and ischemia. We found that intrathecal delivery of an apoE-mimetic peptide caused a significant reduction in post-ischemic brain necrosis, as reflected by decreased reduction in ipsilateral brain weight 7 days following hypoxic-ischemic injury. These results suggest that administration of an apoE-derived therapeutic peptide represents a novel therapeutic strategy in the clinical setting of perinatal hypoxic-ischemic injury. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：305 / 308

页数：4

共 22 条

[1] Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures [J].