Regulatory T Cells: Customizing for the Clinic

被引：36

作者：

Wang, Xuehao ^{[1
]}

Lu, Ling ^{[1
]}

Jiang, Shuiping ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, Nanjing 210029, Peoples R China

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 83期

关键词：

INDIRECT ALLOSPECIFICITY; SELF-TOLERANCE; GENERATION; SUPPRESSION; INDUCTION;

D O I：

10.1126/scitranslmed.3001819

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immune-suppressive cellular immunotherapy requires large numbers of antigen-specific regulatory T cells (T-reg cells), lymphocytes that suppress certain immune responses. Together, three papers in this issue of Science Translational Medicine describe protocols for the ex vivo expansion of human T-reg cells and assess the immune-suppressive function of ex vivo-manipulated T-reg cells after transfer into humanized mouse disease models. Along with recent phase I clinical trial results, these new data provide a platform for clinical use of T-reg cells as personalized therapeutic agents for the treatment of autoimmune diseases, graft-versus-host disease, and transplant rejection.

引用

页数：6

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