Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus

被引：107

作者：

Riemenschneider, J

Garrison, A

Geisbert, J

Jahrling, P

Hevey, M

Negley, D

Schmaljohn, A

Lee, J

Hart, MK

Vanderzanden, L

Custer, D

Bray, M

Ruff, A

Ivins, B

Bassett, A

Rossi, C

Schmaljohn, C ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA

[2] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA

[3] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA

来源：

VACCINE | 2003年 / 21卷 / 25-26期

关键词：

Bacillus anthracis; VEEV; EBOV and MARV; DNA vaccines;

D O I：

10.1016/S0264-410X(03)00362-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiagent DNA vaccines for highly pathogenic organisms offer an attractive approach for preventing naturally occurring or deliberately introduced diseases. Few animal studies have compared the feasibility of combining unrelated gene vaccines. Here, we demonstrate that DNA vaccines to four dissimilar pathogens that are known biowarfare agents, Bacillus anthracis, Ebola (EBOV), Marburg (MARV), and Venezuelan equine encephalitis virus (VEEV), can elicit protective immunity in relevant animal models. In addition, a combination of all four vaccines is shown to be equally as effective as the individual vaccines for eliciting immune responses in a single animal species. These results demonstrate for the first time the potential of combined DNA vaccines for these agents and point to a possible method of rapid development of multiagent vaccines for disparate pathogens Such as those that might be encountered in a biological attack. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4071 / 4080

页数：10

共 52 条

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