Getting knotted: a model for the structure and activation of Spatzle

被引：84

作者：

Mizuguchi, K ^{[1
]}

Parker, JS ^{[1
]}

Blundell, TL ^{[1
]}

Gay, NJ ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(98)01216-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence analyses show that Spatzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spatzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spatzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization.

引用

页码：239 / 242

页数：4

共 32 条

[1] ABOLA EE, 1987, CRYSTALLOGRAPHIC DAT, P107
[2] The SWISS-PROT protein sequence data bank and its new supplement TREMBL
Bairoch, A
Apweiler, R
[J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (01) : 21 - 25
[3] CACTUS PROTEIN-DEGRADATION MEDIATES DROSOPHILA DORSAL-VENTRAL SIGNALING
BELVIN, MP
JIN, YS
ANDERSON, KV
[J]. GENES & DEVELOPMENT, 1995, 9 (07) : 783 - 793
[4] Crystal structure of coagulogen, the clotting protein from horseshoe crab: A structural homologue of nerve growth factor
Bergner, A
Oganessyan, V
Muta, T
Iwanaga, S
Typke, D
Huber, R
Bode, W
[J]. EMBO JOURNAL, 1996, 15 (24) : 6789 - 6797
[5] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES
BERNSTEIN, FC
KOETZLE, TF
WILLIAMS, GJB
MEYER, EF
BRICE, MD
RODGERS, JR
KENNARD, O
SHIMANOUCHI, T
TASUMI, M
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) : 535 - 542
[6] 18TH KREBS,HANS LECTURE - KNOWLEDGE-BASED PROTEIN MODELING AND DESIGN
BLUNDELL, T
CARNEY, D
GARDNER, S
HAYES, F
HOWLIN, B
HUBBARD, T
OVERINGTON, J
SINGH, DA
SIBANDA, BL
SUTCLIFFE, M
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (03): : 513 - 520
[7] Structural and functional diversity in the leucine rich repeat family of proteins
Buchanan, SGS
Gay, NJ
[J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1996, 65 (1-2) : 1 - 44
[8] SETOR - HARDWARE-LIGHTED 3-DIMENSIONAL SOLID MODEL REPRESENTATIONS OF MACROMOLECULES
EVANS, SV
[J]. JOURNAL OF MOLECULAR GRAPHICS, 1993, 11 (02): : 134 - &
[9] REGULATION OF TRANSLATION AND PROTEOLYSIS DURING THE DEVELOPMENT OF EMBRYONIC DORSOVENTRAL POLARITY IN DROSOPHILA - HOMOLOGY OF EASTER PROTEINASE WITH LIMULUS PROCLOTTING ENZYME AND TRANSLATIONAL ACTIVATION OF TOLL RECEPTOR SYNTHESIS
GAY, NJ
KEITH, FJ
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1132 (03) : 290 - 296
[10] CALCULATING THE ELECTROSTATIC POTENTIAL OF MOLECULES IN SOLUTION - METHOD AND ERROR ASSESSMENT
GILSON, MK
SHARP, KA
HONIG, BH
[J]. JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (04) : 327 - 335

← 1 2 3 4 →