Prospective Evaluation of Operating Characteristics of Prostate Cancer Detection Biomarkers

被引：24

作者：

Liang, Yuanyuan ^{[1
,2
,5
]}

Ankerst, Donna P. ^{[1
,2
,6
]}

Ketchum, Norma S. ^{[1
]}

Ercole, Barbara ^{[2
]}

Shah, Girish ^{[7
]}

Shaughnessy, John D. ^{[8
]}

Leach, Robin J. ^{[2
,3
,4
]}

Thompson, Ian M. ^{[2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA

[5] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA

[6] Tech Univ Muenchen, Dept Math, Munich, Germany

[7] Dept Basic Pharmaceut Sci, Monroe, LA USA

[8] Univ Arkansas Med Sci, Donna D & Donald M Lambert Lab Myeloma Genet, Little Rock, AR 72205 USA

来源：

JOURNAL OF UROLOGY | 2011年 / 185卷 / 01期

基金：

美国国家卫生研究院;

关键词：

prostatic neoplasms; prostate-specific antigen; DKK1; protein; human; biological markers; DETECTION RESEARCH NETWORK; PREVENTION TRIAL; ANTIGEN; SERUM; NG/ML; MEN; RISK; VALIDATION; DICKKOPF-1; LEVEL;

D O I：

10.1016/j.juro.2010.08.088

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: We assessed the independent predictive values of the serum markers free prostate specific antigen, proenzyme prostate specific antigen, neuroendocrine marker and Dickkopf-1 compared to serum prostate specific antigen and other standard risk factors for early prostate cancer detection. Materials and Methods: From the prospectively collected SABOR cohort 250 prostate cancer cases, and 250 mean age matched and proportion of African-American race/ethnicity matched controls were selected who had a prior available prostate specific antigen and digital rectal examination. Serum samples were obtained, and free prostate specific antigen, [-2]proenzyme prostate specific antigen, Dickkopf-1 and neuroendocrine marker were measured. AUC, sensitivities and specificities were calculated, and multivariable logistic regression was used to assess the independent predictive value compared to prostate specific antigen, digital rectal examination, family history, prior biopsy history, race/ethnicity and age. Results: The AUCs (95% CI) were 0.76 (0.71, 0.8) for free prostate specific antigen, 0.72 (0.67, 0.76) for [-2] proenzyme prostate specific antigen, 0.76 (0.72, 0.8) for %free prostate specific antigen, 0.61 (0.56, 0.66) for %[-2]proenzyme prostate specific antigen, 0.73 (0.68, 0.77) for prostate health index, 0.53 (0.48, 0.58) for Dickkopf-1 and 0.53 (0.48, 0.59) for neuroendocrine marker. In the 2 to 10 ng/ml prostate specific antigen range the AUCs (95% CI) were 0.58 (0.49, 0.67) for free prostate specific antigen, 0.53 (0.44, 0.62) for [-2] proenzyme prostate specific antigen, 0.67 (0.59, 0.75) for % free prostate specific antigen, 0.57 (0.49, 0.65) for %[-2] proenzyme prostate specific antigen and 0.59 (0.51, 0.67) for phi. Only % free prostate specific antigen retained independent predictive value compared to the traditional risk factors. Conclusions: Free prostate specific antigen retained independent diagnostic usefulness for prostate cancers detected through prostate specific antigen and digital rectal examination screening. Prostate specific antigen isoforms are highly correlated with prostate specific antigen. Future research is needed to identify new markers associated with prostate cancer through different mechanisms.

引用

页码：104 / 110

页数：7

共 30 条

[1] Biology of prostate-specific antigen [J].