Evolution of subclinical hypothyroidism in children treated with antiepileptic drugs

被引：36

作者：

Castro-Gago, Manuel

Ines Novo-Rodriguez, Maria

Gomez-Lado, Carmen

Rodriguez-Garcia, Javier

Rodriguez-Segade, Santiago

Eiris-Punal, Jesus

机构：

[1] Univ Santiago de Compostela, Hosp Clin Univ, Fac Med, Dept Pediat,Serv Neuropediat, Santiago De Compostela 15706, Spain

[2] Univ Santiago de Compostela, Hosp Clin Univ, Fac Med, Serv Lab Cent, Santiago De Compostela 15706, Spain

来源：

PEDIATRIC NEUROLOGY | 2007年 / 37卷 / 06期

关键词：

D O I：

10.1016/j.pediatrneurol.2007.07.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The concentration levels of serum free thyroxine, serum free triiodothyronine, and thyroid-stimulating hormone were measured in 20 children receiving carbamazepine, 32 children receiving valproic acid, and 5 children receiving phenobarbital at the following times: (1) during chronic treatment, and (2) 3 months after the end of treatment with antiepileptic drugs. Patients during chronic treatment revealed significant changes in serum thyroid hormones, especially the children treated with carbamazepine and valproic acid. A number of children receiving long-term therapy with the two last antiepileptic drugs had varying grades of subclinical hypothyroidism. Three months after the end of treatment, a complete return to normal of all parameters was observed. These data demonstrate that the changes induced by these drugs are transient and reversible. (c) 2007 by Elsevier Inc. All rights reserved.

引用

页码：426 / 430

页数：5

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