Immunity to fungal infections

被引：994

作者：

Romani, Luigina ^{[1
]}

机构：

[1] Univ Perugia, Microbiol Sect, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 04期

关键词：

STEM-CELL TRANSPLANTATION; INVASIVE PULMONARY ASPERGILLOSIS; ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; CRYPTOCOCCUS-NEOFORMANS INFECTION; MANNOSE-BINDING LECTIN; C-TYPE LECTIN; CHRONIC DISSEMINATED CANDIDIASIS; INNATE ANTIFUNGAL IMMUNITY; VULVO-VAGINAL CANDIDIASIS; HYPER-IGE SYNDROME;

D O I：

10.1038/nri2939

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fungal diseases represent an important paradigm in immunology, as they can result from either a lack of recognition by the immune system or overactivation of the inflammatory response. Research in this field is entering an exciting period of transition from studying the molecular and cellular bases of fungal virulence to determining the cellular and molecular mechanisms that maintain immune homeostasis with fungi. The fine line between these two research areas is central to our understanding of tissue homeostasis and its possible breakdown in fungal infections and diseases. Recent insights into immune responses to fungi suggest that functionally distinct mechanisms have evolved to achieve optimal host-fungus interactions in mammals.

引用

页码：275 / 288

页数：14

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