Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning

被引：303

作者：

Brandon, Mark P. ^{[1
]}

Bogaard, Andrew R. ^{[1
]}

Libby, Christopher P. ^{[1
]}

Connerney, Michael A. ^{[1
]}

Gupta, Kishan ^{[1
]}

Hasselmo, Michael E. ^{[1
]}

机构：

[1] Boston Univ, Dept Psychol, Ctr Memory & Brain, Grad Program Neurosci, Boston, MA 02215 USA

来源：

SCIENCE | 2011年 / 332卷 / 6029期

关键词：

FREELY MOVING RATS; ENTORHINAL CORTEX; PHASE PRECESSION; REPRESENTATION; MEMORY; HIPPOCAMPUS; MODULATION; WORKING;

D O I：

10.1126/science.1201652

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Grid cells recorded in the medial entorhinal cortex of freely moving rats exhibit firing at regular spatial locations and temporal modulation with theta rhythm oscillations (4 to 11 hertz). We analyzed grid cell spatial coding during reduction of network theta rhythm oscillations caused by medial septum (MS) inactivation with muscimol. During MS inactivation, grid cells lost their spatial periodicity, whereas head-direction cells maintained their selectivity. Conjunctive grid-by-head-direction cells lost grid cell spatial periodicity but retained head-direction specificity. All cells showed reduced rhythmicity in autocorrelations and cross-correlations. This supports the hypothesis that spatial coding by grid cells requires theta oscillations, and dissociates the mechanisms underlying the generation of entorhinal grid cell periodicity and head-direction selectivity.

引用

页码：595 / 599

页数：5

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