Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature

被引:88
作者
Geetha, D [1 ]
Zachary, JB [1 ]
Baldado, HM [1 ]
Kronz, JD [1 ]
Kraus, ES [1 ]
机构
[1] Johns Hopkins Bayview Med Ctr, Baltimore, MD USA
关键词
anemia; immunoglobulin; organ recipient; parvovirus;
D O I
10.1034/j.1399-0012.2000.140612.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
Human Parvovirus B19 (PV B19) is one of the several recently described 'emerging viruses' and has been identified as the etiological agent of 'fifth disease' in childhood. Human PV B19, which is the etiological agent of transient erythroblastopenia in hemolytic anemia, is also a recognized rare cause of red cell aplasia in immunocompromised patients, including transplant recipients. To date, 26 cases of PV B19-induced red cell aplasia have been reported in solid organ transplant recipients. Twelve patients had cyclosporine-based immunosuppression and 14 had tacrolimus-based immunosuppression. Sixteen of these patients required treatment with commercial intravenous immunoglobulin alone, 1 required treatment with intravenous immunoglobulin and plasmapheresis, 4 required intravenous immunoglobulin and erythropoietin, 1 required treatment with intravenous immunoglobulin and conversion of tacrolimus to cyclosporine, 1 had improvement in hematocrit with erythropoietin alone and in 3 patients the disease was self-limiting. Herein, we report a case of pure red cell aplasia caused by acute PV B19 infection in a renal transplant recipient in whom the immunosuppressive regimen included prednisone, mycophenolate mofetil and tacrolimus and the red cell aplasia resolved with discontinuation of mycophenolate mofetil.
引用
收藏
页码:586 / 591
页数:6
相关论文
共 35 条
[1]   EPIDEMIC ERYTHEMA INFECTIOSUM [J].
AGER, EA ;
CHIN, TDY ;
POLAND, JD .
NEW ENGLAND JOURNAL OF MEDICINE, 1966, 275 (24) :1326-&
[2]   INTRAVENOUS IMMUNOGLOBULIN - INDUCED OSMOTIC NEPHROSIS [J].
AHSAN, N ;
PALMER, BF ;
WHEELER, D ;
GREENLEE, RG ;
TOTO, RD .
ARCHIVES OF INTERNAL MEDICINE, 1994, 154 (17) :1985-1987
[3]  
Ahsan N, 1997, CLIN TRANSPLANT, V11, P265
[4]   DUAL INFECTION WITH HUMAN HERPESVIRUS TYPE-6 AND PARVOVIRUS B19 IN A RENAL-TRANSPLANT RECIPIENT [J].
ALKHALDI, N ;
WATSON, AR ;
HARRIS, A ;
IRVING, WL .
PEDIATRIC NEPHROLOGY, 1994, 8 (03) :349-350
[5]  
ANDERSON MJ, 1991, TXB HUMAN VIROLOGY, P1012
[6]  
Anderson T.W., 1986, ECON THEOR, V2, P1
[7]   ENCEPHALITIS ASSOCIATED WITH ERYTHEMA INFECTIOSUM [J].
BALFOUR, HH ;
SCHIFF, GM ;
BLOOM, JE .
JOURNAL OF PEDIATRICS, 1970, 77 (01) :133-+
[8]  
Bergen GA, 1996, J HEART LUNG TRANSPL, V15, P843
[9]  
BERTONI E, 1995, NEPHROL DIAL TRANSPL, V10, P1462
[10]   PARVOVIRUS B19 INFECTION AND HEMATOPOIESIS [J].
BROWN, KE ;
YOUNG, NS .
BLOOD REVIEWS, 1995, 9 (03) :176-182