Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

被引：92

作者：

Horvath, TL ^{[1
]}

Diano, S

Leranth, C

Garcia-Segura, LM

Cowley, MA

Shanabrough, M

Elsworth, JD

Sotonyi, P

Roth, RH

Dietrich, EH

Matthews, RT

Barnstable, CJ

Redmond, DE

机构：

[1] Yale Univ, Sch Med, Dept Obstet Gynecol, 333 Cedar St,FMB 339, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA

[4] Yale Univ, Sch Med, Dept Ophthalmol Visual Sci, New Haven, CT 06520 USA

[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA

[6] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06520 USA

[7] CSIC, Inst Cajal, E-28002 Madrid, Spain

[8] Oregon Hlth & Sci Univ, Vollum Inst, Beaverton, OR 97006 USA

[9] Szent Istvan Univ, Fac Vet Sci, Dept Anat & Histol, H-1078 Budapest, Hungary

[10] St Kitts Biomed Res Fdn, Basseterre, St Kitts & Nevi

来源：

ENDOCRINOLOGY | 2003年 / 144卷 / 07期

关键词：

D O I：

10.1210/en.2003-0163

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

引用

页码：2757 / 2760

页数：4

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