Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations

被引:81
作者
Augat, P [1 ]
Link, T [1 ]
Lang, TF [1 ]
Lin, JC [1 ]
Majumdar, S [1 ]
Genant, HK [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol, Osteoporosis & Arthrit Res Grp, San Francisco, CA 94143 USA
关键词
biomechanics; bone structure; bone strength; osteoporosis; quantitative computed tomography;
D O I
10.1016/S1350-4533(98)00001-0
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
To associate the mechanical anisotropy of trabecular bone with the relationship between bone mineral density (BMD) and mechanical properties, 97 cubic specimens of human trabecular bone were imaged with computed tomography. Bone cubes from the spine, the calcaneus, the distal, and the proximal femur were rested multidirectionally to measure their compressive stiffness and to calculate their ratios of mechanical anisotropy, The ultimate strength was determined in a destructive test in cephalo-caudal (c-c) direction. Compressive stiffness was largest in the c-c direction for the specimens from the spine, as well as the distal and the proximal femur, but not the calcaneus. Anisotropy ratios in c-e direction were larger at the distal femur and the spine than in the proximal femur. The predictive power of BMD for the mechanical properties varied with anatomical location and strongly depended on the loading direction. While at the spine the c-c stiffness was highly correlated to BMD (r(2) = 0.73), the perpendicular directions showed only modest correlations (r(2) < 0.53), The correlations of mechanical properties with BMD were greatest at locations where the anisotropy was less pronounced (proximal femur) or rather uniform (spine). The data suggest that BMD can be most successfully applied to determine the mechanical properties in the principal loading direction, which from a clinical perspective may be most relevant. (C) 1998 IPEM. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:124 / 131
页数:8
相关论文
共 43 条
[1]  
[Anonymous], 1994, OSTEOPOROSIS
[2]  
Augat P, 1996, J BONE MINER RES, V11, P1356
[3]  
BLACK DM, 1992, J BONE MINER RES, V7, P633
[4]   MECHANICAL PROPERTY DISTRIBUTIONS IN THE CANCELLOUS BONE OF THE HUMAN PROXIMAL FEMUR [J].
BROWN, TD ;
FERGUSON, AB .
ACTA ORTHOPAEDICA SCANDINAVICA, 1980, 51 (03) :429-437
[5]   COMPRESSIVE BEHAVIOR OF BONE AS A 2-PHASE POROUS STRUCTURE [J].
CARTER, DR ;
HAYES, WC .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1977, 59 (07) :954-962
[6]   EVALUATION OF ORTHOGONAL MECHANICAL-PROPERTIES AND DENSITY OF HUMAN TRABECULAR BONE FROM THE MAJOR METAPHYSEAL REGIONS WITH MATERIALS TESTING AND COMPUTED-TOMOGRAPHY [J].
CIARELLI, MJ ;
GOLDSTEIN, SA ;
KUHN, JL ;
CODY, DD ;
BROWN, MB .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (05) :674-682
[7]   AGE-RELATED REDUCTIONS IN THE STRENGTH OF THE FEMUR TESTED IN A FALL-LOADING CONFIGURATION [J].
COURTNEY, AC ;
WACHTEL, EF ;
MYERS, ER ;
HAYES, WC .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1995, 77A (03) :387-395
[8]   THE RELATIONSHIP BETWEEN THE ELASTICITY TENSOR AND THE FABRIC TENSOR [J].
COWIN, SC .
MECHANICS OF MATERIALS, 1985, 4 (02) :137-147
[9]   APPENDICULAR BONE-DENSITY AND AGE PREDICT HIP FRACTURE IN WOMEN [J].
CUMMINGS, SR ;
BLACK, DM ;
NEVITT, MC ;
BROWNER, WS ;
CAULEY, JA ;
GENANT, HK ;
MASCIOLI, SR ;
SCOTT, JC ;
SEELEY, DG ;
STEIGER, P ;
VOGT, TM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (05) :665-668
[10]   BONE-DENSITY AT VARIOUS SITES FOR PREDICTION OF HIP-FRACTURES [J].
CUMMINGS, SR ;
BLACK, DM ;
NEVITT, MC ;
BROWNER, W ;
CAULEY, J ;
ENSRUD, K ;
GENANT, HK ;
PALERMO, L ;
SCOTT, J ;
VOGT, TM .
LANCET, 1993, 341 (8837) :72-75