Antidepressant-induced mania, rapid cycling and the serotonin transporter gene polymorphism

被引:63
作者
Rousseva, A
Henry, C
van den Bulke, D
Fournier, G
Laplanche, JL
Leboyer, M
Bellivier, F
Aubry, JM
Baud, P
Boucherie, M
Buresi, C
Ferrero, F
Malafosse, A
机构
[1] Hop Henri Mondor & Albert Chenevier, Psychiat Serv, Assistance Publ Hop Paris, Creteil, France
[2] Hop Charles Perrens, UICA, Psychiat Serv, Bordeaux, France
[3] Univ Paris 05, UFR Sci Pharmaceut & Biol, Biol Cellulaire Lab, Paris, France
[4] INSERM, U513, Fac Med, Unite Neurobiol & Psychiat, Creteil, France
[5] Hop Lariboisiere, Assistance Publ Hop Paris, Lab Cent Biochim & Biol Mol, F-75475 Paris, France
[6] Hop Cantonal Univ Geneva, Dept Psychiat, Geneva, Switzerland
关键词
serotonin transporter gene; affective disorder; antidepressant-induced mania; rapid cycling; candidate symptoms;
D O I
10.1038/sj.tpj.6500156
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The genes involved in the serotonin system are major candidates in association studies on affective disorders and responses to antidepressants. We studied a functional polymorphism of the serotonin transporter (5-HTT) gene (a 44 bp insertion/deletion in the 5-HTT-linked polymorphic region (5-HTTLPR)) and lifetime history of antidepressant-induced mania (AIM) in a population of 305 patients with bipolar affective disorder. AIM was defined using a broad definition and a restrictive definition. No association was found between the 's' allele of the 5-HTTLPR and AIM for either definition. However, we found an association between the 5-HTTLPR and lifetime history of rapid cycling in a subsample of patients (for allele and genotype distributions: exact probability, p=0.0009 and chi(2)=9.4; df=1; p=0.002, respectively). These results may help to explain the conflicting association results obtained with the 5-HTT gene polymorphism, in particular with AIM. Indeed, the precise phenotype associated with the 5-HTT gene is unclear. The association between the 's' allele and rapid cycling may provide further evidence for an association between the 5-HTTLPR 's' allele and a pattern of affective instability.
引用
收藏
页码:101 / 104
页数:4
相关论文
共 19 条
[1]  
ALTSHULER LL, 1995, AM J PSYCHIAT, V152, P1130
[2]  
[Anonymous], 1994, Am J Psychiatry, V151, P1
[3]   Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders [J].
Bellivier, F ;
Szöke, A ;
Henry, C ;
Lacoste, J ;
Bottos, C ;
Nosten-Bertrand, M ;
Hardy, P ;
Rouillon, F ;
Launay, JM ;
Laplanche, JL ;
Leboyer, M .
BIOLOGICAL PSYCHIATRY, 2000, 48 (04) :319-322
[4]   Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression [J].
Bellivier, F ;
Henry, C ;
Szöke, A ;
Schürhoff, F ;
Nosten-Bertrand, M ;
Feingold, J ;
Launay, JM ;
Leboyer, M ;
Laplanche, JL .
NEUROSCIENCE LETTERS, 1998, 255 (03) :143-146
[5]  
Benedetti F, 1999, AM J PSYCHIAT, V156, P1450
[6]   The serotonin transporter in the midbrain of suicide victims with major depression [J].
Bligh-Glover, W ;
Kolli, TN ;
Shapiro-Kulnane, L ;
Dilley, GE ;
Friedman, L ;
Balraj, E ;
Rajkowska, G ;
Stockmeier, CA .
BIOLOGICAL PSYCHIATRY, 2000, 47 (12) :1015-1024
[7]   Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene [J].
Courtet, P ;
Baud, P ;
Abbar, M ;
Boulenger, JP ;
Castelnau, D ;
Mouthon, D ;
Malafosse, A ;
Buresi, C .
MOLECULAR PSYCHIATRY, 2001, 6 (03) :338-341
[8]   Rapid-cycling bipolar disorder - An overview of research and clinical experience [J].
Kilzieh, N ;
Akiskal, HS .
PSYCHIATRIC CLINICS OF NORTH AMERICA, 1999, 22 (03) :585-+
[9]   Serotonin transporter gene polymorphism and antidepressant response [J].
Kim, DK ;
Lim, SW ;
Lee, S ;
Sohn, SE ;
Kim, S ;
Hahn, CG ;
Carroll, BJ .
NEUROREPORT, 2000, 11 (01) :215-219
[10]   Have some guidelines for the treatment of acute bipolar depression gone too far in the restriction of antidepressants? [J].
Möller, HJ ;
Grunze, H .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2000, 250 (02) :57-68