Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species

被引：22

作者：

Killday, KB

Yarwood, D

Sills, MA

Murphy, PT

Hooper, JNA

Wright, AE

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

[2] Novartis Inst Biomed Res, Summit, NJ 07901 USA

[3] Australian Inst Marine Sci, Townsville, Qld 4810, Australia

[4] Queensland Museum, Brisbane, Qld 4101, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期

关键词：

D O I：

10.1021/np000546z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC50 of 13 muM.

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页码：525 / 526

页数：2

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